Hydrochloric Acid → HCID 57230929, compound

HRID 1733272Notes

Reaction equation

HRID 1733272 reaction equation
Cl.[C:2]([C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[CH2:14]([C:16]([CH3:18])=[O:17])[CH3:15]>CCOCC>[C:2]([C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[C:14]([CH3:15])[C:16](=[O:17])[CH3:18])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6569Methyl Ethyl KetoneHCID 703244-tert-Butylbenzaldehyde

Product 1

HCID 57230929HCID 57230929, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

300 g of 32% hydrochloric acid are added dropwise at 15°-20° C. over a period of 1 hour to a mixture of 300 g of p-tert.-butyl-benzaldehyde and 300 g of methyl ethyl ketone and the mixture is left to stir at room temperature for 22 hours. Subsequently, the mixture is taken up in 200 ml of ether, washed with water and saturated sodium bicarbonate solution, dried over sodium sulphate and concentrated. By fractional distillation there is obtained pure 4-(p-tert.butyl-phenyl)-3-methyl-3-buten-2-one of boiling point 120° C./0.03 Torr.

Workup

  1. waitthe mixture is left
  2. washwashed with water and saturated sodium bicarbonate solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated
  5. distillationBy fractional distillation there

Sources & evidence

ORD record
ord-87ea757bf782431bb87fe417af67e85b
Source dataset
uspto-grants-1980_12
Patent number
US04241058

Reaction notes

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