Dimethylcarbamoyl Chloride → HCID 12791208, compound

HRID 1733300Notes

Reaction equation

HRID 1733300 reaction equation
[CH3:1][N:2]([CH3:11])[CH2:3][CH2:4][NH:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1.C(N(CC)CC)C.[CH3:19][N:20]([CH3:24])[C:21](Cl)=[O:22]>C1C=CC=CC=1>[CH3:19][N:20]([CH3:24])[C:21]([N:5]([CH2:4][CH2:3][N:2]([CH3:11])[CH3:1])[C:6]1[S:7][CH:8]=[CH:9][N:10]=1)=[O:22]

Participants

5

Reactant 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 21826856HCID 21826856, compound

Product 1

HCID 12791208HCID 12791208, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Following the procedure of Example 1C using 18.2 g. (0.1065 moles) of N,N-dimethyl-N'-(2-thiazolyl)-1,2-ethane diamine, 12.1 g. (0.120 moles) of triethylamine, 12.5 g. (0.116 moles) of dimethylcarbamoyl chloride and 135 ml. of dry benzene, there is obtained 20.1 g. of N,N-dimethyl-N'-(2-dimethylaminoethyl)-N'-(2-thiazolyl) urea as an oil which is distilled at 108°-110° C., at 0.02 mm. of Hg.

Workup

  1. distillationof N,N-dimethyl-N'-(2-dimethylaminoethyl)-N'-(2-thiazolyl) urea as an oil which is distilled at 108°-110° C., at 0.02 mm. of Hg

Sources & evidence

ORD record
ord-27c1310339514c91be4af1e8ef1c47a2
Source dataset
uspto-grants-1980_12
Patent number
US04241072

Reaction notes

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