Methyl iodide → HCID 178502511, compound

HRID 1733363Notes

Reaction equation

HRID 1733363 reaction equation
[NH:1]=[C:2]1[C:15](NC(NC(OC)=O)=S)=[C:14](CC2C=CC=CC=2)[C:13](Cl)=[C:4]([C:5](C2C=CC=CC=2)=O)[CH:3]1Cl.[OH-].[Na+].CI.N=[C:38]1[C:51]([NH:52][C:53](=[N:56][C:57]([O:59][CH3:60])=[O:58])[S:54][CH3:55])=[CH:50][CH:49]=[C:40]([C:41]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[O:42])[CH:39]1CC1C=CC=CC=1>CN(C)C=O.O>[NH:1]=[C:2]1[CH:15]=[CH:14][CH:13]=[C:4]([CH2:5][C:43]2([C:41](=[O:42])[C:40]3[CH:49]=[CH:50][C:51]([NH:52][C:53](=[N:56][C:57]([O:59][CH3:60])=[O:58])[S:54][CH3:55])=[CH:38][CH:39]=3)[CH:44]=[CH:45][CH:46]=[CH:47][CH2:48]2)[CH2:3]1

Participants

7

Reactant 4

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 131711972HCID 131711972, compoundHCID 178502513HCID 178502513, compound

Product 1

HCID 178502511HCID 178502511, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-imino(2,6-dichloro)phenylmethyl-4-(3-carbomethoxythioureido)benzophenone (2.43 g.; 0.005 mole) in dimethylformamide (100 ml.) is added water (5.0 ml.) and then sodium hydroxide (50% aqueous; 0.4 g.; 0.005 mole). The solution is stirred for 11/2 hours and then methyl iodide (0.71 g.; 0.005 mole) is added. The solution is stirred for one-half hour. The precipitate which forms is collected by filtration and dried to afford 1.3 g. of 3-iminophenylmethyl-4-(3-carbomethoxy-S-methylisothioureido)benzophenone, m.p. 63°-68° C. (dec.).

Workup

  1. stirringThe solution is stirred for one-half hour
  2. filtrationThe precipitate which forms is collected by filtration
  3. customdried
  4. customto afford 1.3 g

Sources & evidence

ORD record
ord-81546d23750d4d809de6bec770b3c9d3
Source dataset
uspto-grants-1980_12
Patent number
US04241079

Reaction notes

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