Methanol → HCID 86737401, compound

HRID 1733382Notes

Reaction equation

HRID 1733382 reaction equation
[C:1]([NH:5][C:6](=[S:19])[NH:7][C:8]1[CH:14]=[C:13]([S:15][CH2:16][CH2:17][CH3:18])[CH:12]=[CH:11][C:9]=1[NH2:10])([O:3][CH3:4])=[O:2].CO[C:22]1[CH:23]=[CH:24][C:25]([CH:28]=O)=[CH:26][CH:27]=1.[CH3:30][OH:31]>>[NH:10]=[C:9]1[CH:11]=[CH:12][C:13]([O:31][CH3:30])([S:15][CH2:16][CH2:17][CH3:18])[C:14]([CH2:28][C:25]2[CH:26]=[CH:27][CH:22]=[CH:23][CH:24]=2)=[C:8]1[NH:7][C:6]([NH:5][C:1]([O:3][CH3:4])=[O:2])=[S:19]

Participants

4

Reactant 3

HCID 887MethanolHCID 312444-MethoxybenzaldehydeHCID 20301198HCID 20301198, compound

Product 1

HCID 86737401HCID 86737401, compoundYield 79%

Conditions

Temperature
10 °C

Procedure

To a suspension of 2-(3-carbomethoxy thioureido)-4-propylthioaniline (9.0 g; 0.03 mole) in methanol (100 ml) cooled to 10° C., there is added p=anisaldehyde (4.08 g; 0.03 mole). The mixture is stirred at 10° C. for 1 hr. and at room temperature for 18 hrs. The suspension that forms is vacuum filtered and the filter cake air dried to afford 1-imino-(4-methoxy)phenylmethyl-2-(3-carbomethoxythioureido)-4-propylthiobenzene (9.9 g,; 79%), m.p. 141°-144° C.

Workup

  1. waitand at room temperature for 18 hrs
  2. filtrationfiltered
  3. customthe filter cake air dried

Sources & evidence

ORD record
ord-f35bbc02673f4ef1be3bb98e3f0fb595
Source dataset
uspto-grants-1980_12
Patent number
US04241079

Reaction notes

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