Hydrochloric Acid → HCID 20299085, compound

HRID 1733414Notes

Reaction equation

HRID 1733414 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].C([O:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:35])(=[N:24][S:25]([C:28]2[CH:34]=[CH:33][C:31]([CH3:32])=[CH:30][CH:29]=2)(=[O:27])=[O:26])=[O:23])=[CH:18][C:17]=1[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=O)C1C=CC=CC=1.Cl>CO>[CH2:36]([C:17]1[CH:18]=[C:19]([S:22]([CH3:35])(=[N:24][S:25]([C:28]2[CH:29]=[CH:30][C:31]([CH3:32])=[CH:33][CH:34]=2)(=[O:27])=[O:26])=[O:23])[CH:20]=[CH:21][C:16]=1[OH:15])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 88780631HCID 88780631, compound

Product 1

HCID 20299085HCID 20299085, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

500 ml of a 10% sodium carbonate solution was added to a solution of the oil of Step C in 250 ml of methanol and the mixture was stirred for 3 hours at 60° C. and was then cooled to room temperature. 100 ml of 20% hydrochloric acid were added to the mixture which was then extracted with chloroform. The organic phase was evaporated to dryness under reduced pressure and the residue was triturated with petroleum ether to obtain 40 g of 2-hexyl-4-(S-methyl-N-tosyl-sulfonimidoyl)-phenol melting at 109°-110° C.

Workup

  1. temperaturewas then cooled to room temperature
  2. extractionwas then extracted with chloroform
  3. customThe organic phase was evaporated to dryness under reduced pressure
  4. customthe residue was triturated with petroleum ether

Sources & evidence

ORD record
ord-d7bf8d78a4b3434f8efcbb7080b94e16
Source dataset
uspto-grants-1980_12
Patent number
US04242267

Reaction notes

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