Methylamine → HCID 20300060, compound

HRID 1733554Notes

Reaction equation

HRID 1733554 reaction equation
C([O:3][C:4](=O)[CH2:5][CH2:6][N:7]1[C:12](=[O:13])[CH:11]=[CH:10][CH:9]=[N:8]1)C.[CH3:15][NH2:16]>C(O)C>[CH3:15][NH:16][C:4](=[O:3])[CH2:5][CH2:6][N:7]1[C:12](=[O:13])[CH:11]=[CH:10][CH:9]=[N:8]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20300059HCID 20300059, compound

Product 1

HCID 20300060HCID 20300060, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

Next a mixture of 1.96 g (0.01 mole) of ethyl-3-(3-oxo-2-pyridazinyl)propionate and 20 ml of methylamine (30% ethanol solution was stirred at 40° C. for 30 hours and distilled to give white crystals. Recrystallization from ethanol gave 1.6 g (82% yield of N-methyl-3-(3-oxo-2-pyridazinyl)propionamide, m.p. 94°-96° C.

Workup

  1. distillationdistilled
  2. customto give white crystals
  3. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-73bc2c82c892427582a9a3e94637d11d
Source dataset
uspto-grants-1980_12
Patent number
US04242512

Reaction notes

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