HCID 9834448, compound → Hydrochloric Acid

HRID 1733914Notes

Reaction equation

HRID 1733914 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:23]=[CH:24][C:25]3[O:29][C:28]([C:30](O)=[O:31])=[CH:27][C:26]=3[CH:33]=2)[CH2:18][CH2:17]1)#[N:2].CS([O-])(=O)=O.[Cl:39]C1C=CC=C[N+:41]=1C>>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][N:19]([C:22]2[CH:23]=[CH:24][C:25]3[O:29][C:28]([C:30](=[O:31])[NH2:41])=[CH:27][C:26]=3[CH:33]=2)[CH2:20][CH2:21]1)#[N:2].[ClH:39]

Participants

4

Reactant 2

HCID 9834448HCID 9834448, compoundHCID 112015695-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxylic acid

Product 2

HCID 313Hydrochloric AcidHCID 6918314Vilazodone

Procedure

Analogously to Example 3, starting from 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carboxybenzofuran-5-yl)piperazine reaction with 2-chloro-l-methylpyridinium methanesulfonate gives 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine, m.p. 269-272° (hydrochloride).

Sources & evidence

ORD record
ord-3f263869f6464ca99454d09ebadc95d0
Source dataset
uspto-grants-1996_07
Patent number
US05532241

Reaction notes

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