Sodium Hydroxide → HCID 19438862, compound

HRID 1733918Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:25]=[C:26]3[C:31](=[CH:32][CH:33]=2)[O:30][CH:29]=[CH:28][C:27]3=[O:34])[CH2:20][CH2:19]1)=O.[Al].[Li].[OH-].[Na+]>C1COCC1>[OH:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]2[CH:25]=[C:26]3[C:31](=[CH:32][CH:33]=2)[O:30][CH:29]=[CH:28][C:27]3=[O:34])[CH2:22][CH2:23]1

Participants

Conditions

Temperature: 25 °C

Procedure

A solution of 3.6 g of 1-[4-(5-methoxycarbonylindol-3-yl)butyl]-4-(chromen-4-on-6-yl)piperazine in 40 ml of THF is added dropwise with stirring at room temperature to a suspension of 0.6 g of lithium aluminum hyride in 20 ml of THF. The mixture is then stirred for a further hour at 25° C., 20 ml of dilute sodium hydroxide solution are added, the mixture is filtered and the filtrate is worked up in the customary manner. 1-[4-(5-Hydroxymethylindol-3-yl)butyl]-4-(chromen-4-on-6-yl)piperazine is obtained.

Workup

filtrationthe mixture is filtered

Sources & evidence

ORD record: ord-c82f444e464c4973b8f1d98b9cef666e
Source dataset: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05532241

Reaction notes

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