Triethylamine → HCID 19699051, compound

HRID 1734000Notes

Reaction equation

HRID 1734000 reaction equation
NC1C=CC(C([CH:8]2[CH2:14][N:13]=[C:12]3[N:15]=[CH:16][CH:17]=[CH:18][C:11]3=[C:10]3[N:19]=[N:20][CH:21]=[C:9]23)=O)=CC=1.C([N:26]([CH2:29][CH3:30])CC)C.[C:31]1([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:32]([C:37](Cl)=[O:38])=[CH:33][CH:34]=[CH:35][CH:36]=1.[OH-:46].[Na+]>ClCCl.CO>[NH:19]1[C:10]2[C:11]3[CH:18]=[CH:17][CH:16]=[N:15][C:12]=3[N:13]([C:10]([C:9]3[CH:21]=[CH:30][C:29]([NH:26][C:37]([C:32]4[C:31]([C:40]5[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=5)=[CH:36][CH:35]=[CH:34][CH:33]=4)=[O:38])=[CH:14][CH:8]=3)=[O:46])[CH2:14][CH2:8][C:9]=2[CH:21]=[N:20]1

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 19699137HCID 19699137, compound

Product 1

HCID 19699051HCID 19699051, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

As described for Example 1, a solution of 2 mmol of 4-(4-aminobenzoyl)-4,5-dihydropyrazolo[3,4-d]pyrido[2,3-b]azepine and 10 mmol of triethylamine is stirred with [1,1'-biphenyl]-2-carbonyl chloride in dichloromethane for 16 hours at room temperature. The initial solid is stirred with 1N NaOH in methanol as described in Example 1 to give the product as a solid.

Sources & evidence

ORD record
ord-4a2df769fc3a48c680489156d9582b19
Source dataset
uspto-grants-1996_07
Patent number
US05532235

Reaction notes

Loading…