Hydrochloric Acid → HCID 21471989, compound

HRID 1734076Notes

Reaction equation

HRID 1734076 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[CH:10]=[C:11]([CH2:13][CH2:14]Cl)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[O:25][N:24]=[C:23]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[C:22]=2[CH:32]=1.Cl>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[CH:10]=[C:11]([CH2:13][CH2:14][N:29]3[CH2:28][CH2:27][CH:26]([C:23]4[C:22]5[CH:32]=[C:18]([Cl:17])[CH:19]=[CH:20][C:21]=5[O:25][N:24]=4)[CH2:31][CH2:30]3)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 21471781153025-28-6HCID 21472058HCID 21472058, compound

Product 1

HCID 21471989HCID 21471989, compoundYield 43.1%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 0.9 g of 6-acetyl-2-(2-chloroethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 1.0 g of 4-(5-chloro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.7 g of 6-acetyl-2-(2-(4-(5-chloro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 122°-124° C. (decomposition) as a hydrochloride thereof.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-5be703cff7b84aa0a6d49bc965aeb572
Source dataset
uspto-grants-1996_07
Patent number
US05532240

Reaction notes

Loading…