Acetic Acid → HCID 53857553, compound

HRID 1734191Notes

Reaction equation

HRID 1734191 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[CH:6]=O.[CH2:17]([O:19][C:20](=[O:25])[CH2:21][C:22]([CH3:24])=[O:23])[CH3:18].N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[O:23]=[C:22]([CH3:24])[C:21](=[CH:6][C:5]1[CH:4]=[C:3]([C:2]([F:16])([F:15])[F:1])[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=1)[C:20]([O:19][CH2:17][CH3:18])=[O:25]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 8868Ethyl AcetoacetateHCID 1362473,5-Bis(trifluoromethyl)benzaldehyde

Product 1

HCID 53857553HCID 53857553, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound is prepared in a manner analogous to that of Step A of Example 2, using 36.3 grams (0.15 mole) of 3,5-di(trifiuoromethyl)benzaldehyde, 22.0 grams (0.17 mole) of ethylacetoacetate, 2 mL of piperidine, and 3 mL of glacial acetic acid in 250 mL of toluene, yielding ethyl 3-oxo-2-[3,5-di(trifluoromethyl)phenylmethylidene]butanoate.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step A of Example 2

Sources & evidence

ORD record
ord-f3a5fe1f9a594eecb72473909e883e31
Source dataset
uspto-grants-1996_07
Patent number
US05532370

Reaction notes

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