反应详情

To a solution of 1-methyl-4-(3,4-diacetoxybenzoyl)piperazine (295 mg) in methanol (3 ml) was added a saturated potassium carbonate solution in methanol (6 ml) and the mixture was stirred at room temperature for 30 minutes. The mixture was poured into ice water and adjusted to pH 9 with 1N hydrochloric acid. The mixture was extracted several times with a mixture of chloroform and methanol (20:1 V/V) and the organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized by addition of ethyl acetate to give 1-methyl-4-(3,4-dihydroxybenzoyl)piperazine (71 mg) as white crystal.

1. extractionThe mixture was extracted several times
2. additionwith a mixture of chloroform and methanol (20:1 V/V)
3. washthe organic layer was washed with brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was crystallized by addition of ethyl acetate