Water → HCID 19083171, compound

HRID 1734412Notes

Reaction equation

HRID 1734412 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([F:11])[CH:7]=[CH:8][CH:9]=2)[C:4]([S:12](Cl)(=[O:14])=[O:13])=[N:3]1.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17].O>C1COCC1>[C:16]([NH:20][S:12]([C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][C:6]=2[F:11])[N:2]([CH3:1])[N:3]=1)(=[O:14])=[O:13])([CH3:19])([CH3:18])[CH3:17]

Participants

5

Reactant 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 19083160HCID 19083160, compound

Product 1

HCID 19083171HCID 19083171, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Further, 13.9 g (56 mmol) of 1-methyl-4-fluoro-1H-indazole-3-sulfonylchloride in 50 ml of THF, was added to 12.9 g (177 mmol) of t-butylamine in 100 ml of THF, and the mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into a large excess amount of water, whereupon the crystals were collected by filtration and dried in air to obtain 15.9 g (yield: 99.6%) of 3-(N-t-butylsulfamoyl)-1-methyl-4-fluoro-1H-indazole (compound represented by the formula [I-d]) (slightly purple crystals).

Workup

  1. customAfter completion of the reaction
  2. filtrationwere collected by filtration
  3. customdried in air

Sources & evidence

ORD record
ord-6c62a954ecda4a5ba1e1d48cd89ab7c8
Source dataset
uspto-grants-1996_07
Patent number
US05534481

Reaction notes

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