Hydrazine hydrate (1:1) → HCID 19437755, compound

HRID 1734543Notes

Reaction equation

HRID 1734543 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:12]([CH3:13])=[CH:11][C:10]([C:14](OCC)=[O:15])=[C:9]2[C:19](OCC)=[O:20])=[CH:5][CH:4]=1.O.[NH2:27][NH2:28]>COCCOCCOC>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:9]3[C:19](=[O:20])[NH:27][NH:28][C:14](=[O:15])[C:10]=3[CH:11]=[C:12]2[CH3:13])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19437766HCID 19437766, compound

Product 1

HCID 19437755HCID 19437755, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

46.0 g (0.133 mol) of diethyl 1-(4-methoxybenzyl)-5-methylpyrrole-2,3-dicarboxylate and 129.5 ml (2.66 mol) of hydrazine hydrate are reacted at 110° C. for 18 h in 290 ml of diglyme. Purification: precipitation from diisopropyl ether/ethyl acetate. Yield: 87%, m.p.: 300° C.

Workup

  1. customPurification
  2. customprecipitation from diisopropyl ether/ethyl acetate

Sources & evidence

ORD record
ord-28c9e980ad5140ab8d0c97a79bd2c423
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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