Hydrochloric Acid → HCID 19966096, compound

HRID 1734883Notes

Reaction equation

HRID 1734883 reaction equation
[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]([CH3:20])[CH3:19])[C:13]=2[NH:21][C:22](=[O:38])[CH2:23][CH:24]2[C:37]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[O:31][C:30]3[C:25]2=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:6]=[CH:5][N:4]=[CH:3]1>O1CCOCC1.C(Cl)Cl>[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]([CH3:20])[CH3:19])[C:13]=2[NH:21][C:22](=[O:38])[CH2:23][CH:24]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:30]=3[O:31][C:32]3[C:37]2=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19966097HCID 19966097, compound

Product 1

HCID 19966096HCID 19966096, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

0.39 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 192 mg (0.39 mmol) of N-{2-[3-(1-imidazolyl)propyl]oxymethyl-6-isopropyl-phenyl}-2-(9H-xanthen-9-yl)acetamide (prepared as described in Example 195) in 2 ml of methylene chloride, and the resulting mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was dissolved in a small amount of dioxane and, after water had been added, the resulting mixture was lyophilized, to give 206 mg of the title compound as a powder.

Workup

  1. distillationthe resulting mixture was freed from the solvent by distillation under reduced pressure
  2. dissolutionThe resulting residue was dissolved in a small amount of dioxane
  3. additionafter water had been added

Sources & evidence

ORD record
ord-50f1ce641f9b4cf189089c93b5df85fc
Source dataset
uspto-grants-1996_07
Patent number
US05534529

Reaction notes

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