Methanol → HCID 178493811, compound

HRID 1735008Notes

Reaction equation

HRID 1735008 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[NH:14][N:13](C3CCCCO3)[CH:12]([C:21]([F:24])([F:23])[F:22])[CH:11]=2)[N:6]=[N:7][CH:8]=1.CO>Cl.O.C(=O)(O)[O-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[NH:14][N:13]=[C:12]([C:21]([F:24])([F:22])[F:23])[CH:11]=2)[N:6]=[N:7][CH:8]=1

Participants

6

Reactant 2

HCID 887MethanolHCID 67729602HCID 67729602, compound

Product 1

HCID 178493811HCID 178493811, compoundYield 65%

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidCatalystHCID 962WaterSolventHCID 516892Sodium BicarbonateSolvent

Procedure

5-Methoxy-3-[[2-(tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (Compound No. 36, 0.75 g (0.0021 mole), 4 drops of 37% hydrochloric acid, and 10 mL of methanol were heated and held at 50° C. for 1 hour. The mixture was cooled, diluted with 30 ml water and neutralized with sodium bicarbonate. Filtration gave 5-methoxy-3-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (0.36 g, 65% yield) as a white solid.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationFiltration

Sources & evidence

ORD record
ord-c7f814b5d9274e4dbbcf93b3e7f6272b
Source dataset
uspto-grants-1996_07
Patent number
US05536701

Reaction notes

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