Sodium hydride → HCID 12643608, compound

HRID 1735085Notes

Reaction equation

HRID 1735085 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH:13]1([CH2:16]Br)[CH2:15][CH2:14]1.[H-].[Na+]>>[CH:13]1([CH2:16][N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:10]([CH:11]=[O:12])=[C:2]2[Cl:1])[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 81503BromomethylcyclopropaneHCID 3147912-chloro-1H-indole-3-carbaldehyde

Product 1

HCID 12643608HCID 12643608, compoundYield 98.2%

Procedure

Prepared from (1) (18 g), cyclopropylmethyl bromide (16.2 g) and NaH (2.8 g) yielding (4) (23 g), m.p. 108°-109° C.

Sources & evidence

ORD record
ord-92249a3aeb644a4992a9a122b755ce73
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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