Hydrochloric Acid → 4-[(2-phenylbenzoyl)amino]benzoic Acid

HRID 1735232Notes

Reaction equation

HRID 1735232 reaction equation
[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.Cl>C(O)C.[OH-].[Na+]>[C:1]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 7901139Methyl 4-[(biphenyl-2-carbonyl)-amino]-benzoate

Product 1

HCID 105435024-[(2-phenylbenzoyl)amino]benzoic Acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A 3.15 g sample of methyl 4-[([1,1'-biphenyl]-2-carbonyl)amino]benzoate is refluxed for 8 hours in 100 ml of ethyl alcohol and 2.5 ml of 10N sodium hydroxide. The cooled reaction mixture is acidified with hydrochloric acid and the desired product collected and dried to give 2.9 g of the desired product as a solid m.p. 246°-249° C. M+H=318 .

Workup

  1. customThe cooled reaction mixture
  2. customthe desired product collected
  3. customdried

Sources & evidence

ORD record
ord-93ee16081dce48c1b33d701aa0c2bd14
Source dataset
uspto-grants-1996_07
Patent number
US05536718

Reaction notes

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