Hydrochloric Acid → HCID 18917485, compound

HRID 1735256Notes

Reaction equation

HRID 1735256 reaction equation
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24]([C:26]4[C:27]([CH3:32])=[N:28][CH:29]=[CH:30][CH:31]=4)=[O:25])=[N:21][CH:22]=3)=[O:16])[CH2:6][C:5]=12.[ClH:33]>CO>[ClH:33].[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24]([C:26]4[C:27]([CH3:32])=[N:28][CH:29]=[CH:30][CH:31]=4)=[O:25])=[N:21][CH:22]=3)=[O:16])[CH2:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18917486HCID 18917486, compound

Product 1

HCID 18917485HCID 18917485, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.0 g of N-[5-(5H-pyrrolo-[2, 1-c][1,4]benzodiazepin-10(11H) -ylcarbonyl) -2-pyridinyl]-2-methylpyridine-3-carboxamide in 50 ml of methanol is added hydrogen chloride gas. The mixture is stirred at room temperature for 30 minutes and the solvent removed under vacuum. The residue is triturated with ether to give 1.0 g of the desired product as a solid: mass spectrum(CCl) ;459 (M+).

Workup

  1. customthe solvent removed under vacuum
  2. customThe residue is triturated with ether

Sources & evidence

ORD record
ord-99e48577fc62450fb3d2344145efbc82
Source dataset
uspto-grants-1996_07
Patent number
US05536718

Reaction notes

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