Carbon Dioxide → HCID 178468156, compound

HRID 1735381Notes

Reaction equation

HRID 1735381 reaction equation
[OH-].[Na+].[CH2:3]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([F:19])[CH:13]=2)[CH2:8][CH2:7]1)[CH3:4].Cl[CH:21]([F:23])[F:22].C(=O)=O>C1COCC1>[CH2:3]([O:5][C@H:6]1[CH2:7][CH2:8][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH:21]([F:23])[F:22])=[C:14]([F:19])[CH:13]=2)[CH2:10][CH2:11]1)[CH3:4]

Participants

6

Reactant 4

HCID 280Carbon DioxideHCID 6372ChlorodifluoromethaneHCID 14798Sodium HydroxideHCID 178468155HCID 178468155, compound

Product 1

HCID 178468156HCID 178468156, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

11 g of NaOH (32%) are added to a solution of 8.2 of the resultant p-(trans-4-ethoxycyclohexyl)-o-flurophenol in 80 ml of THF and 13.8 g of chlorodifluoromethane are introduced (dry ice reflux condenser). After subsequently stirring for one hour, the solution is decanted off from the precipitate and concentrated to give a residue. Bulb tube distillation gives p-(trans-4-ethoxycyclohexyl)-o-fluorodifluoromethoxybenzene, b.p.1 ~220° C., Tg -62°.

Workup

  1. additionare introduced
  2. customthe solution is decanted off from the precipitate
  3. concentrationconcentrated
  4. customto give a residue
  5. distillationBulb tube distillation

Sources & evidence

ORD record
ord-c67b2bfcd0e849b9a2e589e9bb34b177
Source dataset
uspto-grants-1996_07
Patent number
US05536442

Reaction notes

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