Piperazine, 1-(3-chloropropyl)-4-phenyl- → Hydrochloric Acid

HRID 1735730노트

반응식

HRID 1735730 반응식
[O:1]=[C:2]1[CH:8]([C:9]([O:11][CH3:12])=[O:10])[S:7][C:6]2[CH:13]=[CH:14][CH:15]=[CH:16][C:5]=2[O:4][CH2:3]1.[C:17]1([N:23]2[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][CH2:31][Cl:32])[CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[O:1]=[C:2]1[CH:8]([C:9]([O:11][CH3:12])=[O:10])[S:7][C:6]2[CH:13]=[CH:14][CH:15]=[CH:16][C:5]=2[O:4][CH:3]1[CH2:31][CH2:30][CH2:29][N:26]1[CH2:27][CH2:28][N:23]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:24][CH2:25]1.[ClH:32]

참가 물질

4

반응물 2

HCID 139197Piperazine, 1-(3-chloropropyl)-4-phenyl-HCID 13803747HCID 13803747, 화합물

생성물 2

HCID 313Hydrochloric AcidHCID 19434348methyl 3-oxo-[3-(4-phenylpiperazin-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

실험 절차

Methyl 3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate was condensed with 3-(4-phenylpiperazin-1-yl)propyl chloride in the same manner as in Reference Example 1 to isolate methyl 3-oxo-[3-(4-phenylpiperazin-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate as hydrochloride. Recrystallization from methanol yielded white crystals, melting point 176°-178° C.

출처 및 근거

ORD 기록
ord-4d3e51ffb1b748e680579ffceecfc33c
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05538974

반응 노트

불러오는 중…