Hydrochloric Acid → Benzyl 3-aminopropanoate hydrochloride

HRID 1735942Notes

Reaction equation

HRID 1735942 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[NH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10468829Benzyl 3-(Boc-amino)propanoate

Product 1

HCID 19434764Benzyl 3-aminopropanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound (25) (517 mg, 1.85 mmol) was treated with 4N HCl in dioxane at room temperature for 2 h. The reaction mixture was evaporated at reduced pressure, evaporated from toluene and then dried under vacuum to give crude benzyl β-alaninate hydrochloride which was used without further purification.

Workup

  1. customThe reaction mixture was evaporated at reduced pressure
  2. customevaporated from toluene
  3. customdried under vacuum

Sources & evidence

ORD record
ord-5ad46b5c7d7f4e1fabd57046cb35abc6
Source dataset
uspto-grants-1996_07
Patent number
US05539104

Reaction notes

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