Hydrogen Peroxide → 1-(1-oxidopyridin-6-yl)ethanone

HRID 1735973Notes

Reaction equation

HRID 1735973 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2].OO.C(OCC)(=[O:14])C.CCCCCC>C(O)(=O)C.CO>[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N+:5]=1[O-:14])(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 784Hydrogen Peroxide2×HCID 8058HexaneHCID 8857Ethyl AcetateHCID 142862-Acetylpyridine

Product 1

HCID 3379981-(1-oxidopyridin-6-yl)ethanoneYield 33%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

To a solution of 2-acetylpyridine (0.3 mol) in 150 ml of glacial acetic acid was added with stirring 30% hydrogen peroxide (0.32 mol) and the mixture was allowed to react at 60°-65° C. for 16 hours. An additional 3.3 ml of 30% hydrogen peroxide was added, and the mixture was allowed to react at 70° C. for 2 hours. After cooling, the water was removed by evaporation at reduced pressure to leave a crude liquid residue which was taken up in an equal volume of 50:50 ethyl acetate and hexane, and the components were separated by chromatography on 330 g of silica gel. Gradient elution starting with 50:50 ethyl acetate/hexane to 100% ethyl acetate and then to 5% methanol gave 13.48 g (33% yield) of 2-acetyl-pyridine-N-oxide. 1H NMR (CDCl3): 2.81 (singlet (s), 3H, CH3), 7.34 (multiplet (m), 2H, H4 and H5), 7.71 (doublet (d), 1H, H3), and 8.22 ppm (d, 1H, H5); 13C NMR (CDCl3): 31.3 (CH3), 125.9, 127.4, 128.6, 141.2, and 195.7 ppm (C=O); mass spectrum (DCl) M+H=138 m/e; IR (film) λmax 1686 cm-1 (C=O).

Workup

  1. customto react at 60°-65° C. for 16 hours
  2. customto react at 70° C. for 2 hours
  3. temperatureAfter cooling
  4. customthe water was removed by evaporation at reduced pressure
  5. customto leave a crude liquid residue which
  6. customthe components were separated by chromatography on 330 g of silica gel
  7. washGradient elution

Sources & evidence

ORD record
ord-35bd31bdb41944618f93963b91d14a19
Source dataset
uspto-grants-1996_07
Patent number
US05539117

Reaction notes

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