Diisobutylaluminum hydride → HCID 19434051, compound

HRID 1736027Notes

Reaction equation

HRID 1736027 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:14]([C:15](OCC)=[O:16])=[CH:13][C:12]3[CH:20]=[CH:21][S:22][C:11]=3[S:10]2(=[O:24])=[O:23])[CH:6]=[CH:7][CH:8]=1.CC(C[AlH]CC(C)C)C>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:14]([CH2:15][OH:16])=[CH:13][C:12]3[CH:20]=[CH:21][S:22][C:11]=3[S:10]2(=[O:24])=[O:23])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 19434024HCID 19434024, compound

Product 1

HCID 19434051HCID 19434051, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the product of Step C (5.64 g, 15.45 mmol) in anhydrous THF (150 mL) was treated with DIBAL (66 mmol) in a manner essentially analogous to that described in Example 15, Step D to provide the desired product as a white solid (3.62 g, 73%): mp 141°-143° C.

Sources & evidence

ORD record
ord-c1a357f565fc403db0d7ac22d1de2e29
Source dataset
uspto-grants-1996_07
Patent number
US05538966

Reaction notes

Loading…