Hydrochloric Acid → HCID 9817398, compound

HRID 1736100Notes

Reaction equation

HRID 1736100 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([F:33])[C:5]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH:17]C(=O)C(C)(C)C)=[CH:13][CH:12]=3)=[CH:8][C:7](=[O:24])[C:6]=2[C:25]=1[NH:26]C(=O)C(C)(C)C.Cl>O1CCOCC1>[NH2:26][C:25]1[C:6]2[C:7](=[O:24])[CH:8]=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=3)[O:10][C:5]=2[C:4]([F:33])=[CH:3][C:2]=1[F:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10503983HCID 10503983, compound

Product 1

HCID 9817398HCID 9817398, compoundYield 64.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.42 g of Compound 11 was dissolved in 84 ml of dioxane, 36 ml of concentrated hydrochloric acid was added and the mixture was heated at reflux for 3 hours. The reaction solution was cooled on ice and the precipitated crystals were collected by filtration to give 579 mg (57%) of Compound 12.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureThe reaction solution was cooled on ice
  4. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-8919be3ab7384c93a122fe73dca0aae4
Source dataset
uspto-grants-1996_07
Patent number
US05539112

Reaction notes

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