Hydrochloric Acid → HCID 15346993, compound

HRID 1736105Notes

Reaction equation

HRID 1736105 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:36])[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([N:18](C(=O)C)[CH2:19][CH2:20][CH2:21][N:22]4[C:26](=[O:27])[C:25]5=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]5[C:23]4=[O:32])=[CH:14][CH:13]=3)[O:11][C:6]=2[C:5]([F:37])=[CH:4][C:3]=1[F:38].Cl.[OH-].[Na+]>O1CCOCC1>[NH2:1][C:2]1[C:7]2[C:8](=[O:36])[CH:9]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([NH:18][CH2:19][CH2:20][CH2:21][N:22]4[C:23](=[O:32])[C:24]5=[CH:31][CH:30]=[CH:29][CH:28]=[C:25]5[C:26]4=[O:27])=[CH:16][CH:17]=3)[O:11][C:6]=2[C:5]([F:37])=[CH:4][C:3]=1[F:38]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15346992HCID 15346992, compound

Product 1

HCID 15346993HCID 15346993, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.83 g of Compound 22 was dissolved in 12 ml of dioxane, 8 ml of concentrated hydrochloric acid was added and the mixture was heated at reflux for 4 hours. The reaction solution was cooled on ice and adjusted to pH 8 by addition of a 10N aqueous solution of sodium hydroxide thereto, and the precipitated crystals were collected by filtration to give 605 mg (79%) of Compound 23.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 hours
  3. temperatureThe reaction solution was cooled on ice
  4. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-61c25e91cecb460698feeb2495369fc3
Source dataset
uspto-grants-1996_07
Patent number
US05539112

Reaction notes

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