反应详情

温度

80 °C

A mixture of 4-(n-pentyloxyphenyl)-4'-methoxycarbonylbiphenyl (220 mg, 0.58 mmol) and 5N sodium hydroxide (1.17 mL, 5.88 mmol) in tetrahydrofuran (20 mL) was heated at 80° C. under reflux for a period of 18 h. The cooled mixture was acidified with 1N hydrochloric acid (35 mL) and partitioned between ethyl acetate and water. The organic suspension was washed with water (3×) and brine. The organic layer was then filtered to give the carboxylic acid, 4-(n-pentyloxyphenyl)-4'-carboxybiphenyl (210 mg).

1. temperatureunder reflux for a period of 18 h
2. custompartitioned between ethyl acetate and water
3. washThe organic suspension was washed with water (3×) and brine
4. filtrationThe organic layer was then filtered