反应详情

To a stirred solution of N-Ac-L-Leu-L-Leu-OBn (9.09 g, 23.9 mmol) in EA (100 mL) at R.T. was added 20% palladium hydroxide on carbon (Pd (OH)2 /C) (0.9 g, 10% by weight). The reaction mixture was placed under 20 psi hydrogen (H2). After 1 h the reaction mixture was filtered through celite and concentrated in vacuo to give N-Ac-L-Leu-L-Leu-OH as a white solid (6.0 g, 87.67%): 1H NMR (300 MHz, CDCl3) δ 0.82-0.90 (m, 12H), 1.39-1.82 (m, 9H), 4.18-4.34 (m, 2H), 7.94-8.13 (m, 2H) ppm.

1. filtrationAfter 1 h the reaction mixture was filtered through celite and
2. concentrationconcentrated in vacuo