Serinol → HCID 15428265, compound

HRID 1737194Notes

Reaction equation

HRID 1737194 reaction equation
[NH2:1][CH:2]([CH2:5][OH:6])[CH2:3][OH:4].Br[Si:8]([CH3:11])([CH3:10])[CH3:9]>C[Si](C)(C)N[Si](C)(C)C>[NH2:1][CH:2]([CH2:5][O:6][Si:8]([CH3:11])([CH3:10])[CH3:9])[CH2:3][O:4][Si:8]([CH3:11])([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 68294SerinolHCID 76113Bromotrimethylsilane

Product 1

HCID 15428265HCID 15428265, compound

Reagents, catalysts & solvents 1

HCID 13838HexamethyldisilazaneCatalyst

Procedure

A stirred solution of 1.84 g (20.0 mmol) of serinol in 4.25 mL (20.1 mmol) of hexamethyldisilazane containing 1 drop of bromotrimethylsilane was heated to 180° C. under argon. After 16 h, the reaction mixture was partially cooled and distilled at 0.6 Torr, collecting the fraction with bp 44-47° C. to give title compound as a colorless liquid, 4.05 g, 86%.

Workup

  1. temperaturethe reaction mixture was partially cooled
  2. distillationdistilled at 0.6 Torr
  3. customcollecting the fraction with bp 44-47° C.

Sources & evidence

ORD record
ord-9ac9a0a32e694931903a34902272038a
Source dataset
uspto-grants-1999_10
Patent number
US05962440

Reaction notes

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