Hydrochloric Acid → HCID 21842222, compound

HRID 1737331Notes

Reaction equation

HRID 1737331 reaction equation
[CH:1]([N:4]([CH2:8][C:9]1[O:13][C:12]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=4[C:21](=[O:29])[N:20]([CH3:30])[CH2:19][C:18]=23)=[N:11][CH:10]=1)[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH:5]([N:4]([CH2:8][C:9]1[O:13][C:12]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=4[C:21](=[O:29])[N:20]([CH3:30])[CH2:19][C:18]=23)=[N:11][CH:10]=1)[CH:1]([CH3:3])[CH3:2])([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842223HCID 21842223, compound

Product 1

HCID 21842222HCID 21842222, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.82 g (0.0020 mol) of 3-(5-diisopropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 50 ml of ethyl acetate was treated with 0.57 ml (0.0021 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the white suspension was suction filtered. There was obtained 0.82 g (91%) of 3-(5-diisopropylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as whitish crystals; m.p. 232-235° (dec.).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-d1e16fdc8cfa47728caf41aa641b875c
Source dataset
uspto-grants-1999_10
Patent number
US05962450

Reaction notes

Loading…