Hydrochloric Acid → HCID 135671182, compound

HRID 1737560Notes

Reaction equation

HRID 1737560 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14]([O:20]C4C=CC=CC=4)=[N:15][CH:16]=[N:17]3)=[CH:12][C:11]=2[O:27][CH3:28])[CH:5]=[CH:4][N:3]=1.Cl.C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:20])[NH:15][CH:16]=[N:17]3)=[CH:12][C:11]=2[O:27][CH3:28])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 226249147-((2-Chloro-4-pyridyl)methoxy)-6-methoxy-4-phenoxyquinazoline

Product 1

HCID 135671182HCID 135671182, compoundYield 76%

Conditions

Temperature
85 °C

Procedure

A mixture of 7-((2-chloro-4-pyridyl)methoxy)-6-methoxy-4-phenoxyquinazoline (260 mg, 0.7 mmol) and 2M hydrochloric acid (15 ml) was heated at 85° C. for 2 hours. The mixture was allowed to cool and adjusted to pH6-7 with sodium hydrogen carbonate solution. The resulting precipitate was collected by filtration and dried to give 7-((2-chloro-4-pyridyl)methoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (160 mg, 76%).

Workup

  1. temperatureto cool
  2. filtrationThe resulting precipitate was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-17777fdae99a40cba9633c78d43228a8
Source dataset
uspto-grants-1999_10
Patent number
US05962458

Reaction notes

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