反应详情

温度

60 °C

Silver oxide (255 mg, 1.1 mmol, 2.2 equiv.) is added to a suspension of 10-deacetylbaccatin III (272 mg, 0.5 mmol) in a toluene/methyl iodide mixture (3/2; 2.5 ml) at 0° C. The mixture is allowed to return gradually to room temperature. After reaction for 5 h, the reaction mixture is heated to 60° C. After stirring for 24 h at 60° C, an excess of reagents is added: silver oxide (2×255 mg) and methyl iodide (2×1 ml). After heating for a further 36 hours, the reaction mixture is filtered through a sinter funnel and the filtrate is evaporated. According to the HPLC analysis, the reaction medium contains 11.5% (by internal standardization of the areas) of 7,10-dimethoxy-10-deacetylbaccatin.

1. customto return gradually to room temperature
2. customAfter reaction for 5 h
3. additionan excess of reagents is added
4. temperatureAfter heating for a further 36 hours
5. filtrationthe reaction mixture is filtered through a sinter funnel
6. customthe filtrate is evaporated