Hydrochloric Acid → HCID 21840019, compound

HRID 1739012Notes

Reaction equation

HRID 1739012 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10](=[O:27])[CH2:9]1)=O)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[O:27]=[C:10]1[C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54555641HCID 54555641, compound

Product 1

HCID 21840019HCID 21840019, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a cold (0° C.) solution of ethyl N-tert-butoxycarbonyl-3-oxo-4-(3-methylbenzyl)piperidine-4-carboxylate (1.55 g, 4.13 mmol) in ethyl acetate (75 mL), a stream of anhydrous hydrogen chloride gas was bubbled for 20 min. The resultant mixture was stirred at 0° C. for 1 h, purged with argon for 10 min., and concentrated under vacuum to provide the title compound as white solid.

Workup

  1. custompurged with argon for 10 min.
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-c40320dd57a642adb3ef197b03481f29
Source dataset
uspto-grants-1999_10
Patent number
US05965578

Reaction notes

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