2-Amino-5-ethyl-1,3,4-thiadiazole → HCID 21840882, compound

HRID 1739509Notes

Reaction equation

HRID 1739509 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:7][CH3:8])=[N:5][N:6]=1.[I:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][Br:15])=[CH:12][CH:11]=1>C(O)(C)C>[BrH:15].[CH2:7]([C:4]1[S:3][C:2](=[NH:1])[N:6]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([I:9])=[CH:11][CH:12]=2)[N:5]=1)[CH3:8]

Participants

4

Reactant 2

HCID 264442-Amino-5-ethyl-1,3,4-thiadiazoleHCID 9542584-Iodobenzyl bromide

Product 1

HCID 21840882HCID 21840882, compoundYield 62.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To isopropyl alcohol (10 ml) was added 2-amino-5-ethyl-1,3,4-thiadiazole (645 mg) and 4-iodobenzyl bromide (1.49 g), followed by heating under reflux for 2 hours. After the reaction mixture was cooled, the crystals so precipitated were collected by filtration and dried, whereby 1.33 g of the title compound was obtained.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter the reaction mixture was cooled
  4. customthe crystals so precipitated
  5. filtrationwere collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-97ff8b0d48124cc7b9a281ea7f6b10f5
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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