反应详情

0.58 ml of ethyl diisopropylamine and 0.59 ml of trifluoro-methanesulfonic anhydride were added to a solution of 900 mg of the product of Stage A in 50 ml of acetonitrile and the reaction medium was refluxed for one hour. Then, the solvent was evaporated under reduced pressure and the crude product obtained was chromatographed on silica, eluting with a cyclohexane-ethyl acetate mixture (50-50) to obtain 600 mg of the expected product.

1. temperaturethe reaction medium was refluxed for one hour
2. customThen, the solvent was evaporated under reduced pressure
3. customthe crude product obtained
4. customwas chromatographed on silica
5. washeluting with a cyclohexane-ethyl acetate mixture (50-50)