Hydrochloric Acid → HCID 86754624, Verbindung

HRID 1739782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1739782
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2(O)[CH2:17][CH2:16][C@@H:15]3[C@:10]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=4)([CH2:11][CH2:12][N:13]([CH2:18][CH3:19])[CH2:14]3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl>>[NH4+:13].[OH-:26].[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:9][C@:10]3([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=4)[C@@H:15]([CH2:16][CH:17]=2)[CH2:14][N:13]([CH2:18][CH3:19])[CH2:12][CH2:11]3)[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86754623(+/-)-trans-6-(3-Bromophenyl)-1,2,3,4,4a,5,6,7,8,8a-decahydro-2-ethyl-4a-(3-methoxyphenyl)-6-isoquinolinol

Produkt 2

HCID 14923Ammonium HydroxideHCID 86754624HCID 86754624, VerbindungAusbeute 118,4 %

Versuchsvorschrift

The reaction was conducted as described in Example 2, using 0.44 g (0.99 mmol) of (±)-trans-6-(3-bromophenyl)-1,2,3,4,4a,5,6,7,8,8a-decahydro-2-ethyl-4a-(3-methoxyphenyl)-6-isoquinolinol and 15 ml of 37% HCl. The crude reaction mixture was purified by flash chromatography, eluting with a mixture CH2Cl2 /MeOH/conc. NH4OH 98:2:0.4 respectively, yielding 0.25 g of the title compound.

Aufarbeitung

  1. customThe crude reaction mixture
  2. customwas purified by flash chromatography
  3. washeluting with a mixture CH2Cl2 /MeOH/conc

Quellen und Nachweise

ORD-Eintrag
ord-637aa65fceed4eb7826e910f57122ee6
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05968949

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