Hydroxyamine hydrochloride → HCID 21837527, compound

HRID 1739797Notes

Reaction equation

HRID 1739797 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N:11]2[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)[CH2:4][CH2:3][CH2:2]1.Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+]>C(O)C>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N:11]2[CH2:16][CH2:15][C:14](=[N:19][OH:20])[CH2:13][CH2:12]2)[CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 22122648HCID 22122648, compound

Product 1

HCID 21837527HCID 21837527, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture composed of 1 g (4.32 mmol) of the product obtained in Step 1, 1.26 g of hydroxylamine hydrochloride, 1.26 g of sodium acetate and 20 ml of ethanol are heated at reflux for 1 hour. After removal of the solvent by evaporation, the residue is taken up in 100 ml of methylene chloride, washed with water, dried and evaporated to yield 0.9 g of the expected product.

Workup

  1. temperatureare heated
  2. temperatureat reflux for 1 hour
  3. customAfter removal of the solvent
  4. customby evaporation
  5. washwashed with water
  6. customdried
  7. customevaporated

Sources & evidence

ORD record
ord-1974084df9ef43558e953900ef337ebb
Source dataset
uspto-grants-1999_10
Patent number
US05968954

Reaction notes

Loading…