HCID 21837534, compound → HCID 21837528, compound

HRID 1739800Notes

Reaction equation

HRID 1739800 reaction equation
[C:1]([O:4][CH:5]1[C:14]2[C:9](=[C:10]([N:15]3[CH2:20][CH2:19][C:18](=[N:21]O)[CH2:17][CH2:16]3)[CH:11]=[CH:12][CH:13]=2)[O:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2]>C(O)C.[NH4+].[OH-].[Ni]>[C:1]([O:4][CH:5]1[C:14]2[C:9](=[C:10]([N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[CH:11]=[CH:12][CH:13]=2)[O:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2]

Participants

5

Reactant 1

HCID 21837534HCID 21837534, compound

Product 1

HCID 21837528HCID 21837528, compoundYield 96%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 14923Ammonium HydroxideSolvent

Procedure

0.28 g of the compound of Step 4 is dissolved in a solution of 6 ml of ethanol and 0.3 ml of NH4OH. 0.3 ml of Raney nickel is added and the whole is hydrogenated at room temperature under atmospheric pressure. After filtering off the catalyst, rinsing and evaporating, 0.25 g of the expected product is obtained. Yield: 96%.

Workup

  1. customis hydrogenated at room temperature under atmospheric pressure
  2. filtrationAfter filtering off the catalyst
  3. washrinsing
  4. customevaporating

Sources & evidence

ORD record
ord-c7a6fd3ae2b24e8cb15120a88f8f8752
Source dataset
uspto-grants-1999_10
Patent number
US05968954

Reaction notes

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