Hydrochloric Acid → HCID 21837525, compound

HRID 1739803Notes

Reaction equation

HRID 1739803 reaction equation
C([NH:4][C:5]1([CH3:21])[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[O:19][CH2:18][CH2:17][O:16][C:15]=3[CH:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)(=O)C.Cl.[OH-].[Na+]>>[NH2:4][C:5]1([CH3:21])[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[O:19][CH2:18][CH2:17][O:16][C:15]=3[CH:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 14798Sodium HydroxideHCID 21837530HCID 21837530, compound

Product 1

HCID 21837525HCID 21837525, compoundYield 73.2%

Procedure

0.51 g (1.76 mmol) of the product obtained in Step 2 is treated at reflux for one night with 3 ml of 3N HCl. 1 ml of concentrated HCl is added and the whole is heated at reflux for 24 hours, allowed to cool, rendered basic with 2N NaOH and extracted 3 times with 30 ml of CH2Cl2 each time. The organic phases are washed and then dried. 0.32 g of the expected product is obtained. Yield: 73%.

Workup

  1. temperaturethe whole is heated
  2. temperatureat reflux for 24 hours
  3. temperatureto cool
  4. extractionextracted 3 times with 30 ml of CH2Cl2 each time
  5. washThe organic phases are washed
  6. customdried

Sources & evidence

ORD record
ord-fdcdd2c700b8492eab2445342a3cf4f4
Source dataset
uspto-grants-1999_10
Patent number
US05968954

Reaction notes

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