Diisopropylethylamine → HCID 9884687, compound

HRID 1739809Notes

Reaction equation

HRID 1739809 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH:8]([OH:11])[CH2:9]Br)[O:5][N:4]=1.[F:12][C:13]1[CH:26]=[CH:25][C:16]([C:17]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[CH:15][CH:14]=1.C(N(C(C)C)C(C)C)C>C(O)C>[F:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([CH:19]2[CH2:24][CH2:23][N:22]([CH2:9][CH:8]([C:6]3[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=3)[OH:11])[CH2:21][CH2:20]2)=[O:18])=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27244404-(4-Fluorobenzoyl)piperidineHCID 13626982HCID 13626982, compound

Product 1

HCID 9884687HCID 9884687, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.5 g of 1-(3-methoxy-isoxazol-5-yl)-2-bromoethanol and 4.9 g of 4-(4'-fluorobenzoyl)piperidine and 5.4 ml of N-ethyldiisopropylamine in 160 ml of absolute ethanol was refluxed for 2 hours.

Sources & evidence

ORD record
ord-1b97ea80d9d541fb83c5ad43ba27659e
Source dataset
uspto-grants-1999_10
Patent number
US05968955

Reaction notes

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