HCID 21838184, compound → HCID 19363121, compound

HRID 1740314Notes

Reaction equation

HRID 1740314 reaction equation
FC(F)(F)S(O)(=O)=O.[CH3:9][N:10]([CH3:34])[CH2:11][CH2:12][NH:13][C:14]([C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:32])[F:31])(=[O:29])=[O:28])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20])=[O:15]>C(OCC)(=O)C.O>[CH3:34][N:10]([CH3:9])[CH2:11][CH2:12][NH:13][C:14]([C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:32])[F:31])(=[O:28])=[O:29])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20])=[O:15]

Participants

4

Reactant 1

HCID 21838184HCID 21838184, compound

Product 1

HCID 19363121HCID 19363121, compoundYield 108.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

Methyl 3-[(2-dimethylaminoethyl)carbamoyl]-5-trifluromethylsulfonyloxybenzoate trifluoromethanesulfonate (1.45 g) was dissolved in ethyl acetate (150 ml) and to the mixture water (50 ml) was added. The mixture was adjusted to pH 9 and two layers were separated. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give methyl 3-[(2-dimethylaminoethyl)carbamoyl]-5-trifluoromethylsulfonyloxvbenzoate (1.14 g).

Workup

  1. additionwas added
  2. customwere separated
  3. washThe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-d2b6cd5be87140f0aac7ec4775802403
Source dataset
uspto-grants-1999_10
Patent number
US05968985

Reaction notes

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