反应详情

温度

65 °C

A two-liter, 3-necked, round-bottomed flask equipped with an air condenser and a magnetic stirring plate was charged with N,N-dimethyldodecylamine (297.24 grams, 1.40 moles), 1-bromo-3-chloropropane (220.44 grams, 1.40 moles) and methanol (250 mL). Reaction was maintained at 65° C. for 24 hours. Methanol was removed by rotary evaporation under reduced pressure to yield a brown sludge. To the sludge was added methyl-tert-butylether (2 liters) causing a white solid to form. The mixture was stirred for two hours and a semi-crystalline, white particulate was collected by vacuum filtration. The particulate was dried in a vacuum oven at 35° C. for 24 hours. Yield 228.2 grams (0.61 moles, 44%).

1. customA two-liter, 3-necked, round-bottomed flask equipped with an air condenser
2. customReaction
3. customMethanol was removed by rotary evaporation under reduced pressure
4. customto yield a brown sludge
5. customto form
6. filtrationa semi-crystalline, white particulate was collected by vacuum filtration
7. customThe particulate was dried in a vacuum oven at 35° C. for 24 hours