(-)-Mandelic acid → HCID 131721410, compound

HRID 1740396Notes

Reaction equation

HRID 1740396 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:15]3)[C:9]2=[O:24])=[CH:4][CH:3]=1.[C:25]([OH:35])(=[O:34])[C@@H:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[OH:27]>C(OCC)(=O)C>[C:25]([OH:35])(=[O:34])[C@@H:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[OH:27].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:18][CH2:19]3)[C:9]2=[O:24])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11914(-)-Mandelic acidHCID 49132091-(4-Chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone

Product 1

HCID 131721410HCID 131721410, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a hot solution of 66.6 g of 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 350 mL of ethyl acetate was added a hot solution of (R)-(-)-mandelic acid in 120 mL of ethyl acetate. After cooling, the precipitated crystals were filtered, washed with ethyl acetate and dried in vacuo to give 36.4 g of the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated crystals were filtered
  3. washwashed with ethyl acetate
  4. customdried in vacuo

Sources & evidence

ORD record
ord-863b5d1590384cdd894169d67c9fd564
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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