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HRID1740399

反应详情

EQUATION

反应方程式

HRID 1740399 的结构方程式

REACTANTS

反应物

2
反应SMILES：O=C(O)[C@@H](O)c1ccccc1
HCID439616

D-2-Hydroxy-2-phenylacetic acid

C8H8O3

反应SMILES：COCCN1CCN(CC2CCN(c3ccc(Cl)cc3)C2=O)CC1
HCID4913209

未命名化合物

PRODUCTS

产物

1
反应SMILES：COCCN1CCN(C[C@@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=C(O)[C@@H](O)c1ccccc1
HCID131721411

未命名化合物

收率 35.7%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Under heating, 152 mg of (S)-(+)-mandelic acid was added to a solution of 352 mg of 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 3 mL of ethyl acetate. After cooling, the precipitated crystals were filtered and dried in vacuo to give 180 mg of the title compound.

WORKUP

后处理

  1. temperatureUnder heating
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered
  4. customdried in vacuo