(S)-mandelic acid → HCID 131721411, compound

HRID 1740399Notes

Reaction equation

HRID 1740399 reaction equation
[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][CH:21]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:27][CH2:26]3)[C:20]2=[O:35])=[CH:15][CH:14]=1>C(OCC)(=O)C>[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@@H:21]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:29][CH2:30]3)[C:20]2=[O:35])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 439616(S)-mandelic acidHCID 49132091-(4-Chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone

Product 1

HCID 131721411HCID 131721411, compoundYield 35.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Under heating, 152 mg of (S)-(+)-mandelic acid was added to a solution of 352 mg of 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 3 mL of ethyl acetate. After cooling, the precipitated crystals were filtered and dried in vacuo to give 180 mg of the title compound.

Workup

  1. temperatureUnder heating
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-2f91f5c76c964de38b9388afdd7a8b4e
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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