Hydrogen Bromide → HCID 86754637, compound

HRID 1740402Notes

Reaction equation

HRID 1740402 reaction equation
[BrH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH3:24])[CH2:17][CH2:16]3)[C:10]2=[O:25])=[CH:5][CH:4]=1>C(O)C>[BrH:1].[BrH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][O:23][CH3:24])[CH2:19][CH2:20]3)[C:10]2=[O:25])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 9892249MS-377

Product 1

HCID 86754637HCID 86754637, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a mixture of 379 mg of 47% hydrobromic acid aq. and 10 mL of ethanol was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethanol. The mixture was stirred at room temperature and then cooled. The precipitated solid was filtered and dried to give 488 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-91484dc786b5474bb8a80c3959bf4da8
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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