L-Tartaric acid → HCID 86754644, compound

HRID 1740411Notes

Reaction equation

HRID 1740411 reaction equation
[C:1]([OH:10])(=[O:9])[C@@H:2]([C@H:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:26][CH2:25]3)[C:19]2=[O:34])=[CH:14][CH:13]=1>C(O)C>[OH2:3].[OH2:32].[C:6]([C@@H:4]([C@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[C:6]([C@@H:4]([C@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:28][CH2:29]3)[C:19]2=[O:34])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 444305L-Tartaric acidHCID 9892249MS-377

Product 1

HCID 86754644HCID 86754644, compoundYield 59.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 300 mg of L-tartaric acid in 20 mL of ethanol was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethanol. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 205 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-4ae401aace154bfda157373c40038613
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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