HRID1740412

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID439655

未命名化合物

反应SMILES：COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1

HCID9892249

MS-377

C18H26ClN3O2

PRODUCTS

产物

反应SMILES：COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=C(O)[C@@H](O)[C@H](O)C(=O)O.O=C(O)[C@@H](O)[C@H](O)C(=O)O

HCID86754645

未命名化合物

收率 67.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A solution of 75 mg of D-tartaric acid in 3 mL of ethanol was added to a solution of 176 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 3 mL of ethanol. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 110 mg of the title compound.

WORKUP

后处理

temperaturecooled
filtrationThe precipitated solid was filtered
customdried

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-63fa68a4bfd545d5be9d9107933c31bd
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05969138
来源说明: uspto-grants-1999_10

反应SMILES

[C:1]([OH:10])(=[O:9])[C@H:2]([C@@H:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:26][CH2:25]3)[C:19]2=[O:34])=[CH:14][CH:13]=1>C(O)C>[C:6]([C@H:4]([C@@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[C:6]([C@H:4]([C@@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:28][CH2:29]3)[C:19]2=[O:34])=[CH:14][CH:13]=1