HCID 21838732, compound → HCID 53783208, compound

HRID 1740500Notes

Reaction equation

HRID 1740500 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]1[C:8]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:9]=2[S:10][C:11]=1C(O)=O)=[O:5])[CH3:2]>O1CCCC1>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:8]2[C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[CH:11][S:10][C:9]=2[CH:15]=1

Participants

3

Reactant 1

HCID 21838732HCID 21838732, compound

Product 1

HCID 53783208HCID 53783208, compoundYield 200%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

11.4 g of 3-[(ethoxycarbonyl)amino]-6-methoxybenzo[b]thiophene-2-carboxylic acid are heated at 220-225° C. A vitreous gum is obtained which is taken up in tetrahydrofuran until dissolved. The solvent is evaporated under reduced pressure and the residue is purified on a silica column with a 10/90 mixture of ethyl acetate and cyclohexane. 19.4 g of product are obtained.

Workup

  1. customA vitreous gum is obtained which
  2. dissolutionuntil dissolved
  3. customThe solvent is evaporated under reduced pressure
  4. customthe residue is purified on a silica column with a 10/90 mixture of ethyl acetate and cyclohexane

Sources & evidence

ORD record
ord-d5331d8e6ef94da788fd13a1fab071ae
Source dataset
uspto-grants-1999_10
Patent number
US05969146

Reaction notes

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