反应详情

A suspension of 1-(2-chloro-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene (3.90 g) in hydrazine hydrate (17.8 ml) is refluxed for 9 hours. The mixture is stirred at room temperature for 10 minutes, and further stirred under ice-cooling for 10 minutes. To the mixture are added methylene chloride and water, and the methylene chloride layer is separated, washed, dried, and concentrated under reduced pressure to remove the solvent. The residue is dissolved in hot ethanol (20 ml), and allowed to cool overnight to give 1-(2-hydrazino-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene (3.19 g).

1. temperatureis refluxed for 9 hours
2. stirringfurther stirred under ice-
3. temperaturecooling for 10 minutes
4. customthe methylene chloride layer is separated
5. washwashed
6. customdried
7. concentrationconcentrated under reduced pressure
8. customto remove the solvent
9. dissolutionThe residue is dissolved in hot ethanol (20 ml)
10. temperatureto cool overnight