Oxalyl chloride → HCID 21833062, compound

HRID 1740755Notes

Reaction equation

HRID 1740755 reaction equation
[C:1]([C:4]1[O:5][C:6]2[C:7](=[C:9]([C:15]([OH:17])=O)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH:8]=1)(=[O:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[C:1]([C:4]1[O:5][C:6]2[C:7](=[C:9]([C:15]([Cl:21])=[O:17])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH:8]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 218330412-Acetyl-7-methoxy-4-benzofurancarboxylic acid

Product 1

HCID 21833062HCID 21833062, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

2-Acetyl-7-methoxybenzofuran-4-carboxylic acid (0.12 g) was suspended in anhydrous dichloromethane (4 ml) at room temperature under nitrogen and oxalyl chloride (0.1 ml) added followed by 3 drops of N,N-dimethylformamide. Evaporation in vacuo after 2 h afforded the title compound as a yellow solid (~0.5 g).

Workup

  1. customEvaporation in vacuo after 2 h

Sources & evidence

ORD record
ord-1152c1ba688c4eefa53105193e9a629d
Source dataset
uspto-grants-1999_10
Patent number
US05972936

Reaction notes

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